Products
Product Literature
Data file
28-9785-70
MicroCal VP-DSC Systems
Application Notes
28-9870-36
DSC theory and practice
28-9870-37
DSC in the development of liquid formulations for protein biopharmaceuticals
28-9870-39
Shelf-life determination of low molecular weight compounds
28-9870-40
Usage of DSC for more economical process development
28-9870-41
Development and Optimization of protein formulations
28-9870-42
Using DSC to understand the correlation between thermal stability and protein stability
28-9870-45
Better guidance in antibody therapeutics process development using DSC
28-9870-46
Differential factors that contribute to the intrinsic and designed stability of antibody Fab regions
Differential Scanning Calorimetry (DSC)
Differential Scanning Calorimetry (DSC) is unsurpassed for understanding the stability of biological systems. DSC directly measures heat changes that occur in biomolecules during controlled increase or decrease in temperature, making it possible to study materials in their native state.
DSC measures the enthalpy (∆H) of unfolding due to heat denaturation. A biomolecule in solution is in equilibrium between the native (folded) conformation and its denatured (unfolded) state. The higher the thermal transition midpoint (Tm), when 50% of the biomolecules are unfolded, the more stable the molecule. DSC is also used to determine the change in heat capacity (ΔCp) of denaturation.
Products
MicroCal offers a range of Differential Scanning Calorimeters designed to meet the needs of life scientists, ranging from the industry standard VP-DSC to the advanced automated VP-Capillary DSC.
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